To understand the basis of sex differences in autoimmune diseases. Regulation of transcription factors and gene activation events by immunomodulators (e.g. natural and environmental estrogens)
To investigate microRNA regulation of the immune system in health and autoimmune diseases. To understand the interactions of microRNAs with other epigenetic factors (altered methylation and acetylation) that influence lupus and inflammation.
To study the role of neutrophils in lupus models.
To decipher the complex interactions of microbiome with epigenetics and inflammation in lupus