Immuno-oncology: This research focuses on the studying the role of tumor micro-environment and the activation of immuno-regulatory signaling pathways in tumor infiltrating immune cells (dendritic cells, macrophages and T cells), which contributes to the evasion of host anti-tumor immune responses. The goal of this research is to identify the novel immuno-regulatory pathway in both tumor cells and tumor infiltrating immune cells that play a critical role in the suppression of anti-tumor immunity. Dr. Suryawanshi’s lab is interested in using genomic approaches, cellular immunology, clinical data samples, conditional knock-out mice and mouse syngenic tumor models. This information will be further utilized to target various components of signaling mechanisms to design and develop novel cancer immunotherapies.
